Abstract
The risk of severe COVID-19 outcomes in people with inflammatory diseases (IMIDs) and on immune modifying drugs may not be fully mediated by comorbidities. With the approval of NHS England, we conducted a cohort study, using OpenSAFELY, analysing routinely-collected primary care data linked to hospital admission, death and previously unavailable hospital prescription data. We used Cox regression (adjusting for confounders/confounders and mediators) to estimate hazard ratios (HR) comparing risk of COVID-19-death, death/critical care admission, and hospitalisation (March to September 2020) in: 1) people with IMIDs compared to the general population; and 2) people with IMIDs on targeted immune modifying drugs (e.g., biologics) compared to those on standard systemic treatment (e.g., methotrexate).
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