073 Posterior reversible encephalopathy syndrome (PRES) complicating anti-NMDA receptor encephalitis (NMDARE) with ovarian teratoma

Abstract

IntroductionAnti-N-methyl-D-aspartate receptor antibody-associated encephalitis (NMDARE) is a form of autoimmune encephalitis typically affecting young women, often associated with an ovarian teratoma. Clinical features include psychiatric disturbances, seizures, dyskinesia, dysautonomia, and cardiac dys- rhythmias. Here we present a case of NMDARE complicated by posterior reversible encephalopathy syndrome (PRES). This complication has not been reported previously.CaseA 17-year-old girl presented with acute psychosis. The neurological examination was unremark- able. MRI brain revealed left hippocampal T2 signal hyperintensity; there was a CSF lymphocytosis. NMDA-receptor antibodies in serum and CSF were detected and intravenous methylprednisolone was commenced. Progressive agitation lead to ITU admission. Plasma exchange and intravenous immuno- globulins were administered. MRI pelvis revealed a left ovarian cyst which was removed (laparoscopic salpingo-oophrectomy). Gross inspection and histopathology confirmed an ovarian teratoma. Persistently elevated blood pressure was noted for a week on ITU, associated with clinical deterioration. Rituximab was administered. A repeat MRI brain the next day revealed hyperintensities in temporo-parietal and occipital regions consistent with PRES. The second dose of rituximab was withheld. Clinical and radiologi- cal improvement was noted after a week, and the patient was discharged home.DiscussionEncephalitis mediated dysautonomia may lead to disruption of cerebral autoregulation cul- minating in PRES. The administration of rituximab may also have contributed. This case exemplifies the uncommon complications associated with NMDARE.dr.dvinayan@gmail.com