Abstract
The spleen has important functions in innate and acquired immunological responses, and splenectomy leads to risk for overwhelming infections [1]. The microcirculation in spleen is only partly understood, and knowledge of the local interstitial fluid composition and changes during sepsis can offer new insights in the systemic inflammatory response syndrome.
Highlights
The spleen has important functions in innate and acquired immunological responses, and splenectomy leads to risk for overwhelming infections [1]
Our model shows typically hemodynamic changes previously described to be associated with an initial endotoxin reaction in pigs [2]
We show that it is possible to isolate lymph from spleen
Summary
The spleen has important functions in innate and acquired immunological responses, and splenectomy leads to risk for overwhelming infections [1]. The microcirculation in spleen is only partly understood, and knowledge of the local interstitial fluid composition and changes during sepsis can offer new insights in the systemic inflammatory response syndrome
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