069 Non-supervised gene expression profiling of circulating regulatory T cells in severe Korean atopic dermatitis patient by scRNA-seq

Abstract

Atopic dermatitis (AD), also known as atopic eczema, is a chronic inflammatory skin disease caused by a combination of factors, such as neuroinflammation, microbiome, barrier dysfunction, and immune dysregulation. Affecting more than 15% of children and 1-3% of adults, the disease has negatively impacted countless patients worldwide, and more research on pathological features is imperative to develop effective patient care. Our group has previously discovered that circulating regulatory T cells in AD patients have diverse immune phenotypes and contribute to their immune dysregulation among European-American patients.