Abstract
During the last years there has been a renewed interest in using extracorporeal membrane oxygenation (ECMO) to treat severe ARDS. ECMO may correct hypoxemia but may also aid in protecting the lungs [1]. However, there is scarce data about the optimal way to ventilate the lungs during ECMO. Experimental models of acute lung injury with ECMO are usually too short.
Highlights
During the last years there has been a renewed interest in using extracorporeal membrane oxygenation (ECMO) to treat severe ARDS
scarce data about the optimal way to ventilate the lungs during ECMO
animals were immediately connected to a saline primedMEDOS Hilite ECMO circuit by inserting a AVALON 23F double-lumen cannula through the external jugular vein
Summary
During the last years there has been a renewed interest in using extracorporeal membrane oxygenation (ECMO) to treat severe ARDS. ECMO may correct hypoxemia but may aid in protecting the lungs [1]. There is scarce data about the optimal way to ventilate the lungs during ECMO. Experimental models of acute lung injury with ECMO are usually too short. Animals were immediately connected to a saline primedMEDOS Hilite ECMO circuit by inserting a AVALON 23F double-lumen cannula through the external jugular vein. Blood flow was set at 60-70% of cardiac output. Respiratory and hemodynamic data, as well as plasma and BAL samples were collected at times 0, 3, 6, 12, 18 and 24h. After euthanizing animals at time 24h tissue samples were extracted from the lungs
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