Abstract
Psoriasis is a chronic inflammatory skin disease with a strong Th17-skewed immune phenotype. It has been generally accepted that regulatory T cells in the lesional psoriasis skin have a functional impairment. However, circulating Cutaneous Leukocyte Associated antigen(CLA)+ regulatory T cell which potentially migrated out from the lesional skin has not yet been explored well so far especially in Asians. Herein, to investigate whether circulating CLA+regulatory T cells show aberrant immuno-phenotype compared to CLA- regulatory T cells, we've collected a total of sixty-four psoriasis patient blood in a single center with age/sex control in Korea.
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