Abstract
Allergen-specific immunotherapy (ASIT) is an effective treatment that can induce clinical and immunological tolerance to pathogenic allergens for atopic dermatitis (AD). The main mechanism of ASIT therapy is to induce the allergen-specific regulatory T (Treg) cells. Recently, transcriptomic and functional analyses of Treg cells have identified three specialized subsets based on RORγt (Rorc) and GATA3 expression along with Foxp3. Although skin Treg cells are composed largely of Foxp3+GATA3+ Tregs cells, recent studies have shown that Foxp3+RORγt+ Treg cells have immune-regulatory function in different peripheral and intestinal related organs.
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