0667 The effect of tinnitus on sleep architecture in patients with depression

Abstract

Abstract Introduction There is an established link between tinnitus (an auditory symptom affecting sound in the ear or head, in the absence of auditory stimulus) and depression in adults. However, there is a lack of research into the effect of tinnitus on sleep architecture in this depression. Methods Female participants (n=149) with sleep disturbance and temporomandibular joint (TMJD) pain were recruited as part of a treatment trial. Data were used to identify a cohort of participants with clinically significant depressive symptoms (CES-D >16), with and without tinnitus. We examined the pre-randomization polysomnography (PSG) dataset, and calculated sleep architecture, and relative spectral power (Alpha, beta, theta, delta). We compared cohorts using independent t-tests, testing for differences in architectural and spectral sleep parameters, controlling for anxiety symptoms. Results 14 females (mean age = 41.76) reporting current tinnitus were age and depression severity matched with 14 females reporting no tinnitus (mean age = 41.27). Groups did not differ significantly in age (p = 0.91), BMI (p = 0.868), race (p = 0.328) or severity of depressive symptoms (CES-D: 23.93 No tinnitus vs 25.07 Tinnitus, p = 0.540), but the tinnitus group reported significantly higher anxiety (GAD-7: 9.43 no tinnitus vs 13.36 Tinnitus, p = 0.016). Data indicated TMJD patients with tinnitus had greater N2 sleep percentage (24.243% no tinnitus vs 57.200% Tinnitus, p = 0.033) compared with controls. There were no significant differences in N1% (4.2% No tinnitus vs 3.7% Tinnitus, p = 0.874), SWS% (23.164% No tinnitus vs 17.236% Tinnitus, p = 0.217) or REM% (26.386% No Tinnitus vs 21.88% Tinnitus, p = 0.238) between groups. Analysis of spectral data showed no significant differences in relative alpha (0.129 No tinnitus, 0.143 Tinnitus, p = 0.099), beta (0.186 No tinnitus vs 0.188 Tinnitus, p = 0.814), theta (0.123 No Tinnitus vs 0.125 Tinnitus, p = 0.069), or delta power (0.360 Tinnitus vs 0.346 Tinnitus, p = 0.399). Conclusion Our results indicate an association between tinnitus and increased N2% in TMJD participants reporting sleep disturbance and depressive symptoms. The effect of tinnitus on objective sleep parameters, in the context of depressive symptoms warrants further study. Support (If Any) This research study was supported financially by the NIH Grant R01 DE019731 (Haythornthwaite, JA and Smith, MT).[MR1] [MR1]Don’t include this in the main body, it’ll use too many words. If there’s a section on the submission portal to include this, add it. If not can just put the grant reference (as one word) in brackets after “treatment trial”