062 High-throughput quantitative proteomics unveils HIF1α as a driver of IL17A-induced metabolic alterations favoring hyperproliferation in keratinocytes

Abstract

The cytokine IL17A, primarily secreted by Th17 cells, is known to play a crucial role in the pathogenesis of psoriasis where it augments keratinocyte hyperproliferation and inflammation. Although, the signaling cascades downstream of this critical cytokine, and the resultant proteomic and phenotypic alterations remain to be exhaustively explored. The findings of such an exploration could be harnessed to devise safer and more effective therapies. Accordingly, LC-MS/MS-based label-free quantitative proteomic analysis was performed on human primary keratinocytes (HPKs) stimulated with IL17A.