0613 POLYSOMNOGRAPHICAL AND NEUROPSYCHOLOGICAL DIFFERENCES BETWEEN APOE4 AND NON-APOE4 GROUPS: A PRELIMINANARY STUDY

Abstract

APOE-4 isoforms have been associated to sleep apnea and cognitive decay. The objective of the present study is to evaluate sleep and cognitive differences in sleep apnea patients with and without APOE4 allele by means of polysomnography and neuropsychological tests. We selected twenty-one sleep apnea patients, 11 females and 10 males, aging 33–79 years from Sao Paulo Hospital sleep care unit. Patients underwent clinical interview, full night polysomnography, neuropsychological evaluation and APOE genotyping. Patients were classified in groups according to the presence APOE4 allele. Differences between groups were assessed by One-way ANOVA. Patients with APOE4 allele presented lower BMI, smaller neck and waist circumference, shorter REM sleep latency, and lower REM sleep respiratory disturbance index (REM RDI) (p<0.05). Patients with APOE4 allele presented higher retroactive interference mean (IDR) in Rey Auditory Verbal Learning Test (p<0.05). Patients with sleep apnea and APOE4 allele differed from patients without APOE4 allele in biometrical, polysomnographic and neuropsychological parameters. Patients without APOE4 allele showed less favorable sleep apnea, biometric and neuropsychological characteristics. REM sleep RDI was higher in patients with APOE4 allele. FAPESP.