Abstract
Atopic dermatitis (AD) is a chronic, recurrent, itchy, inflammatory skin disease. The coexistence of anxiety, depression, and social withdrawal is problematic in AD. Although an association between AD and anxiety and depressive behavior has been observed in humans and in a few mouse models, the detailed mechanisms are unknown. To address this issue, we analyzed the mental state of mice using AD models. We sensitized mice with 3% oxazolone (OXA) and then repeatedly applied 0.6% OXA to the ears of mice 3 times per week for 4 weeks.
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