Abstract
Objective: The effect of estrogen deficiency on bone is one of the most clearly demonstrated adverse consequences of hypogonadism in women. Estrogen replacement is essential for maintaining bone health as well as managing low bone mineral density (BMD) and osteoporosis due to hypogonadism in adolescents and young women [1]. Although there is no agreed consensus on optimum hormone replacement regimens for this group of patients, 17 β estradiol (E2) appears to have a more beneficial effect on BMD compared to ethinylestradiol [2,3].
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