0589. Pravastatin exerts opposite effects on splanchnic microcirculatory oxygenation during sham or septic conditions in an animal model of polymicrobial sepsis

C Beck,I Bauer,C Vollmer,O Picker,F Barthel,A Herminghaus

doi:10.1186/2197-425x-2-s1-p34

Abstract

In addition to lipid-lowering effects HMG-CoA reductase inhibitors like pravastatin also modulate the microcirculation [1]. The exact mechanisms are yet unknown and results are heterogeneous, with both positive and negative effects on endothelial microvascular function [2, 3] being reported.

Highlights

In addition to lipid-lowering effects HMG-CoA reductase inhibitors like pravastatin modulate the microcirculation [1]
The aim of this study was to evaluate the effects of pravastatin on the microcirculatory oxygenation of the colon in a rodent model of polymicrobial sepsis
1.) In pravastatin pre-treated sham animals the microcirculatory oxygenation μHbO2 declined by 9.8 ± 9.4% with no change in the NaCl group

Summary

Introduction

In addition to lipid-lowering effects HMG-CoA reductase inhibitors like pravastatin modulate the microcirculation [1]. Introduction In addition to lipid-lowering effects HMG-CoA reductase inhibitors like pravastatin modulate the microcirculation [1]. The exact mechanisms are yet unknown and results are heterogeneous, with both positive and negative effects on endothelial microvascular function [2,3] being reported.

Objectives

Results

Conclusion