057 Gender differences following percutaneous coronary intervention

Abstract

It has been postulated that women have higher adverse events with percutaneous coronary intervention (PCI) when compared with men, but as PCI has improved, it also appears this has been reduced or eliminated. In this study, we examine a cohort of women and men undergoing PCI for all indications and we compare the results between the two groups particularly the mortality. The study examined patients (100 men and 100 women) who underwent PCI from 2002 to 2007 in cardiology department of Hédi Chaker Hospital. Women were more aged than men. Morbidity was higher in female group (frequency of diabetis: p<0,05). PCI was more achieved in case of stable angina (p<0,05). Les femmes avaient plus d’atteinte polytronculaire (p<0,05), d’atteintes des segments moyens et distaux et plus des lésions serrées (p = NS), longues et calcifiées (p<0,05). Women angiographic characteristics were: high rate of multitroncular disease (p<0,05), distal lesions (p<0,05), longer lesion and calcification (p<0,05). 259 stents were deployed. Woman artery diameter was thinner than man (p<0,05). Stent length was more important in female population (p<0,05). Global Angiographic success was 94% in global population without differences between the two groups. Inhospital major cardiovascular events (MACE) were more frequent in women (p = 0,05). At a mean follow-up of 31 months, short and mid term MACE were similar between the two groups. Nevertheless global MACE rate significantly higher in female group (39% vs. 28%, p<0,05), including especially global mortality (13% vs. 3%, p<0,05). Retenosis rate was comparable between the two groups. In earlier trials PCI has been associated with more procedure related complications in women than men, but this difference between genders has been less pronounced in more recent studies.