Abstract

The objectives of this clinical trial are to assess safety, tolerability, and pharmacokinetics of IMU-935. This is a first-in-human, double-blind, randomized, placebo-controlled clinical trial comprising three parts. In part A, healthy volunteers in cohorts of 8 subjects each were enrolled and received single ascending doses of IMU-935 (25 to 400 mg) or placebo (ratio 3:1). In part B, healthy volunteers will receive multiple ascending doses of IMU-935 or placebo for 14 days, and in part C, patients with moderate to severe plaque-type psoriasis will take either two different dose levels of IMU-935 or placebo.

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