Abstract
Tissue-resident memory T cells (TRM) differ fundamentally from their circulating counterparts, central and effector memory T cells (TCM ,TEM). The epigenetic mechanisms and transcription factor networks by which they maintain their distinct differentiation states remain obscure. Here we compared genome-wide maps of chromatin accessibility of CD8+ TRM ,TCM, TEM generated by skin vaccinia virus (VACV) infection using Assay for Transposase-Accessible Chromatin sequencing (ATAC-seq). Principal component analysis (PCA) segregated TRM, TCM, TEM into 3 clearly separate clusters which were also distinct from naïve CD8 T cells.
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