Abstract
Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa. Two major clinical subtypes of OLP are described, namely reticular and erosive OLP. Erosive OLP is often refractory to topical and systemic therapy. Reticular OLP is characterized by keratotic lines (Wickham’s striae) that produce a “lacy” pattern, while erosive OLP shows painful erosions, which can extremely affect the quality of life of the patients. The pathogenesis of OLP is not completely understood, but several factors seem to play a pivotal role, including IFN-gamma inducible chemokines and IL-17.
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