0563 Inspiratory Flow Limitation in Non OSA Individuals: Risk Factors and Clinical Complaints After 8 Years of Follow in a General Population

Abstract

Abstract Introduction Inspiratory flow limitation (IFL) indicated by the flattening of inspiratory curve, is a respiratory pattern in polysomnography (PSG) suggested as a parameter used to identify individuals with sleep breathing disorder. The cutoff value is still not well defined. The purpose of this study was to evaluate the frequency and clinical impact of IFL after 8-year follow up ingeneral population. Methods MethodsBaseline sample was derived from a prospective population-based study (Epidemiologic Sleep Study, EPISONO). A total of 1,042 subjects completed the study assessments in 2007 and 712 from these participants were reassessed in 2016.Full night PSG at baseline and follow-up was performed and clinical outcomes were analyzed. IFL was manually scored and TST spent in IFL during sleep was calculated. Results In 2007 and 2016, IFL in non OSA individuals′ mean value was 10.1% and 17.7 % of TST and 95th percentile was 37.8 % and 49.9 % respectively. OSA patients had higher BMI than nonOSA in 2007 (p = 0.01), however, BMI and age were not risk factors to develop OSA or to increase IFL after 8 years. Individuals with IFL that became OSA after 8 years had a higher BMI, regardless of time, than those that did not develop OSA. Individuals who presented <15% of TST with IFL in 2007 and changed to ≥15% in 2016demonstrated significantly worse Beck depression score compared to group that maintained IFL < 5%. Individuals with ≥ 15% of TST with IFL in 2007 and in 2016 also increased depression severity score and Whoqol social relationship and environment domainscompared to the group with <15%. Conclusion Non OSA individuals presented 10.1% in 2007 and 17.7% in 2016 of TST in IFL. After 8 years, individuals with ≥15% of IFL presented worsening of depression severity and sleep quality. Support The authors would like to thank for the support by grants from Associação Fundo de Incentivo a Pesquisa (AFIP), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).