0542 Obstructive sleep apnea in outpatients with COPD at Can Tho University of Medicine and Pharmacy Hospital – An Observational Study

Abstract

Abstract Introduction The concurrence of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) is generally identified as overlap syndrome.This study evaluated biometric characteristics, sleep disorders, and scores comorbidities on OS and OSA groups in outpatients at the Respiratory Units of Can Tho University of Medicine and Pharmacy Hospital (RU-CTUMP); surveyed respiratory symptom severity, airway obstruction, and aerosol treatment characteristics in OS patients; and determined the correlations between sleep disorder severity and specific patient characteristics. Methods A cross-sectional, single-center descriptive study was conducted. We enrolled 48 outpatients at the RU-CTUMP in the study in three months. The patients were divided into two groups with overlapped COPD and OSA (OS, n = 30) vs. OSA-only (n = 18). Patients were asked to complete the demographic questionnaires, Epworth Sleepiness Scale (ESS) scores, STOP-Bang questionnaire, and Snoring Severity Scale (SSS). They were assessed for pulmonary function tests (PFTs) to confirm their COPD diagnosis, overnight respiratory polygraphy (Nox T3x), and Apnea-Hypopnea Index (AHI) to evaluate the severity of OSA, Charlson index to evaluate comorbidities, and their medication history. Results In the OS group, 100% of the patients suffered from dyspnea with the mean mMRC scores of 2.83 ± 0.75, mean FEV1 was 60.07 ± 23.09%, and 86% received inhaled medicine. In both groups, all participants suffered from 1 - ≥ 2 comorbidities. Overlapped patients had more comorbidities than OSA-only patients (Charlson scores of 2.33 and 1.17, respectively). There were significant correlations between the AHI value and the body mass index, neck circumferences, STOP-Bang score, the value of the Snoring Severity Scale, and minimum SpO2 (r = 0.45, 0.43, 0.46, 0.44, -0.69, respectively). In addition, COPD was a risk factor for OSA (OR = 1.125). Conclusion Home sleep testing in outpatients with COPD in RU-CTUMP revealed an increased prevalence of OSA compared to the OSA-only group. One of the most common comorbidities in individuals with overlap syndrome is hypertension, which is at least as common as in sleep apneic-only patients and may contribute to the disease's overall severity and prognosis. Support (if any)