Abstract
Pruritus is common in autoimmune diseases and a prominent symptom especially in patients with dermatomyositis (DM). In contrast, the severity of pruritus in cutaneous lupus erythematosus (CLE) is less severe. Importantly, pruritus is an important symptom to differentiate DM from CLE. It has been found that keratinocytes-derived interleukin (IL)-18 played a pathophysiologic role in DM and IL-18 potentially distinguishes DM from CLE. The present study aimed to investigate the association of IENFD in DM-related pruritus and the possible mechanism.
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