Abstract
There is currently no clear in vitro model to study the Th2 status in atopic dermatitis (AD). Staphylococcus aureus, skin-homing cutaneous lymphocyte-associated antigen (CLA)+ memory T cells and IL-13 are key players in AD. Circulating CLA+ memory T cells reflect the cutaneous abnormalities in AD. We have studied the CLA+/- memory T-cell response to staphylococcal enterotoxin B (SEB) when cocultured with autologous lesional epidermal cells from adult non-treated moderate-to-severe AD patients. Also, plasma and mRNA expression from the lesional skin biopsies were analysed.
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