Abstract
Skin is a uniquely accessible and responsive target for vaccine delivery. Emerging evidence suggests that keratinocytes can modulate skin immunity in response to diverse stimuli, producing either proinflammatory or immune suppressive mediators depending on the nature of the exogenous stress. To improve the immunogenicity of skin targeted vaccines, we engineered keratinocytes to support a proinflammatory local environment. Keratinocytes were genetically engineered to express the stress response transcription factor x-box binding protein 1 (XBP1).
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