052 Factors associated With Hypertensive Crisis Occurrence in Obstructive Sleep Apnea Induced Hypertension Patients

Abstract

Hypertensive crisis is an urgency/emergency condition. The association of obstructive sleep apnea (OSA) and hypertensive crisis is strong. The prevalence and risk factors for hypertensive crisis occurrence in OSA induced hypertension are limited. This study aimed to determine prevalence and risk factors for hypertensive crisis development in hypertensive patients caused by OSA. The inclusion criteria were all hypertensive patients caused by OSA. The diagnosis of OSA induced hypertension was made by presence of apnea-hyponea index (AHI) of more than 5 events/hour without evidence of other causes of hypertension. Patients were categorized by occurrence of hypertensive crisis. Factors associated with hypertensive crisis were computed by multivariate logistic regression analysis. There were 121 patients met the study criteria. Of those, 19 patients (15.70%) had history of hypertensive crisis. Those patients in hypertensive crisis group had significant higher systolic and diastolic blood pressure than those without hypertensive crisis patients (177 vs 141 mmHg and 108 vs 85 mmHg; p value <0.001 for both factors). After adjusted for age, sex, and Mallampati classification, only systolic blood pressure was independently associated with hypertensive crisis with adjusted odds ratio (95% CI) of 1.046 (1.012, 1.080). The prevalence of hypertensive crisis in OSA associated hypertension was 15.70%. High systolic blood pressure was the independent predictor for hypertensive crisis occurrence in hypertensive patients associated with OSA.