052 Cytokine-producing B cell balance associated with skin fibrosis in patients with systemic sclerosis

Abstract

Systemic sclerosis (SSc) is an autoimmune disease characterized by skin and internal organ. Over 90% of patients with SSc are positive for autoantibodies. In addition, the serum levels of B cell activating factor, a potent B cell stimulator, are correlated with SSc severity and activity. Thus, B cells play an important role in SSc pathogenesis. However, two opposing B cell subsets exist: effector B cells (Beffs) and regulatory B cells (Bregs). Interleukin (IL)-6–producing Beffs have been shown to promote scleroderma in a mouse model, whereas IL-10–producing Bregs inhibit sclerodoma development.