Abstract
Patient reported outcomes following radical prostatectomy have focused on physiologic function. To date, no studies have validated Patient Reported Outcome Measurement Information System (PROMIS) Sexual Function and Satisfaction (SexFS) measures of Interest in Sexual Activity and Global Satisfaction with Sex Life in prostate cancer patients, nor have they examined how these measures relate to sexual function. In addition, no prior studies have assessed satisfaction and interest in prostate cancer patients following radical prostatectomy longitudinally. These measures have the potential to add an important element to survivorship care and can impart self-efficacy onto the prostate cancer survivor. The objective of this study was to validate PROMIS SexFS Interest in Sexual Activity and Satisfaction with Sex Life single item measures in men with prostate cancer who underwent radical prostatectomy and examine the longitudinal relationship of these measures with measures of sexual and urinary function. We identified all men who underwent a robotic radical prostatectomy from May 2014- January 2016 in the Michigan Urological Surgery Improvement Collaborative (MUSIC). A single item from the PROMIS Global Satisfaction with Sex Life subdomain (“When you have had sexual activity, how satisfying has it been?”) and a single item from the PROMIS Interest in Sexual Activity subdomain (How interested have you been in sexual activity?”) was administered. Scores for each item were based on a T metric with higher scores indicating higher satisfaction and interest. The MSKCC STAR system was also administered to assess sexual, bowel and urinary function. Convergent and discriminant validity were assessed with Pearson correlation coefficients. In between group differences were evaluated using Fisher’s Exact and chi-squared tests.
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