Abstract
Alopecia areata (AA) is an autoimmune disease characterized by T cell infiltration of the hair follicle. The breakdown of tolerance to the hair follicle is thought to be the driving force in the nonscarring hair loss seen in patients. There are currently no FDA approved treatments for AA. IL-27 plays a pleotropic role across many other autoimmune diseases; however, whether its immunoregulatory effects can be leveraged for therapeutic applications in AA is unknown. To address this, we used an adeno-associated virus (AAV) that drives overexpression of IL-27 in our C3H/HeJ skin graft-induction model of AA.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
