Abstract
Staphylococcus aureus exacerbates barrier dysfunction and immune dysregulation in atopic dermatitis (AD) leading to disease flares. There is an unmet need for a S.aureus vaccine which could transform AD management. Cell mediated immunity is a key correlate of immunity for vaccine targeting. Vaccine induced immunity however, may need to be tailored to specific anatomical sites. This study aimed to investigate S.aureus antigen-specific T cell responses associated with S.aureus flares in paediatric atopic dermatitis, to identify future vaccine targets.
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