Abstract
The association between polymorphisms in the p53 tumour suppressor gene and CAD has been reported. However, not all investigations have been consistent, and this hypothesized association remains controversial. The aim of this study was to investigate the possible association between the MspI in intron 6 polymorphism in the p53 gene and myocardial infarction (MI) in Tunisian subjects. A total of 246 unrelated patients with MI (27-69 years old) and 230 healthy controls (35-69 years old) were included in this study. The MspI polymorphism of the p53 gene was evaluated by PCR-RFLP method. The genotype distribution for the MspI variant of the p53 gene in MI patients (M1M1: n=115, 46.7%; M1M2: n=122, 49.6%; M2M2: n=9, 3.7%) and controls (M1M1: n = 134, 58.3%; M1M2: n = 92, 40.0%; M2M2: n=4, 1.7%) was significantly different (p = 0.029). Similarly, the allelic frequency was also different (p = 0.017). The odds ratio for MI related to the M2 allele was 1.43 (95% CI=1.05 - 1.95). These results suggest that the MspI polymorphism of the p53 gene is associated with MI in Tunisian population.
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