049 Generalized pustular psoriasis (GPP) and palmoplantar pustulosis (PPP) both show upregulation of the IL-36, neutrophil chemokine, and innate pathways that are modulated by spesolimab, an anti-IL-36 receptor antibody, treatment

Abstract

Pustular psoriasis comprises a spectrum of inflammatory skin conditions, including GPP and PPP, characterized by neutrophilic infiltration of the epidermis and development of visible sterile pustules. GPP is a rare, multisystemic, potentially life-threatening, flaring disease, whereas PPP is a localized, relapsing, debilitating, chronic disease. Here, gene and protein expression of lesional and non-lesional skin from 7 patients with a moderate GPP flare, 8 patients with moderate-to-severe PPP, and skin samples from the thigh/back (n=10) or palm/sole (n=6) of healthy donors were compared.