0472 INSOMNIAS IN OSA PATIENTS WITH DIFERENT DEGREES OF SEVERITY: A STEP TOWARDS PHENOTYPING COMISA

Abstract

Abstract Introduction With this pilot study, authors aimed to find how OSA and insomnias (sleep onset and maintenance insomnia) interact. Methods Data from PSG-level 1 consecutive Obstructive Sleep Apnea (OSA) patients were retrospectively collected. Insomnia and OSA severity were assessed. Arousals (A), arousal index (AI), wakefulness after sleep onset (WASO), total sleep time (TST) and sleep eficiency (SE) were used to better characterize insomnias. Epworth Sleepiness Sclae (ESS) was used to assess excessive daytime sleepiness (EDS). Results From 87 OSA patients, 43 (51.8 %): 53.5 % being females (F), where insomniacs (COMISA). Patients with COMISA where distributed as follows: Mild OSA (5 F: 22%; BMI=26.9±4.0 Kg/m2; Age=50.3±15.8 years old - yo; AHI=15.9±13.3 ev/h; ODI3%=4.0±3.9 ev/h; SaO2mean=96.4±0.98 %; SaO2min=89.5±4.2 %) with a TST of 414.5±70.9 min, SE=79.6±13.6 %, WASO=83.7±57.0 min and 182.7±84.8 arousals (AI=26.6±11.1 ev/h); Moderate OSA (8 F: 35%; BMI=28.7±4.7 Kg/m2; Age=53.5±13.4 yo; AHI=24.4±3.1 ev/h; ODI3%=8.8±5.7 ev/h; SAO2mean=95.3±1.2 %; SaO2min=87.7±3.9 %) with a TTS=385.8±69.2 min, SE=80.7±12.6 %, WASO=81.4±62.3 min and 178.8±69.5 arousals (AI=27.5±8.9 ev/h); Severe OSA (10 F: 43 %; BMI=30±5.2 Kg/m2; Age=58.6±7.8 yo; AHI=48.1± 19.9 ev/h; ODI3%=25.4±25.1 ev/h; SaO2mean=94.5±2.4%; SaO2min=82.6±10%) had a TTS=386.5±64.5 min, SE=77.4±11.4%, WASO=93.3±49.8 min and 274.2±95.3 arousals (AI=42.6±12.9 ev/h). The others 40:48.2 % presented with Isolated OSA: Mild OSA (7 F: 39 %; BMI=27.8±3.9 Kg/m2; Age=48.3±12.1 years old - yo; AHI=8.9±3.2 ev/h; ODI3%=2.5±2.7 ev/h; SaO2mean=96.4±0.8%; SaO2min=90.8±2.6%) had a TST of 423.9±36.7 min, SE=86.4±7.3%, WASO=58.1±27.2 min and 151.6±42.1 arousals (AI=21.6±6.5 ev/h); Moderate OSA (7 F: 39%; BMI=27.1±5.4 Kg/m2; Age=53±13.1 yo; AHI=21.2±3.8 ev/h; ODI3%=6.9±3.8 ev/h; SAO2mean=95.9±0.6%; SaO2min=86.7±4.1%) had a TTS=406.3±86.5 min, SE=79.4±15.2%, WASO=77.2.3±68 min and 196.3.8±60.4 arousals (AI= 29.1±6.6 ev/h); Severe OSA (4 F: 22%; BMI=28.3±4.2 Kg/m2; Age=62±12.5 yo; AHI=51.8± 18.7 ev/h; ODI3%=28.5±21.2 ev/h; SaO2mean=93.9±3.5%; SaO2min=81.4±10.2%) had a TTS=385.9±105.7 min, SE=76.2±20.1%, WASO=92.9±80.1 min and 272.7±115.6 arousals (AI=42.5±14.9 ev/h). ESS was 10.1±7.9, 9±5.4 and 8±5.7 for the Mild, Moderate and Severe OSA in COMISA group, and 14.6±7.3, 10.9±5.2 and 5.9±5.2, for the mild, moderate and severe forms of the isolated OSA group. Conclusion Insomnia complaints in OSA patients and PSG correlates seems to indicate clinically relevant COMISA phenotypes that would help to better characterize and manage this condition at different degrees of OSA severity. Support (if any)