044 Possible Preventive Effect of Preoperative Gentamicin on Penile Prosthesis Infection: A Retrospective Comparison of two Different Doses

Abstract

Compare the infection rates of inflatable penile prosthesis (IPP) placement in 2 groups of patients who received 2 different doses of preoperative gentamicin. We retrospectively analyzed 2 groups of patients who underwent IPP placement between April 14, 2012 and April 13, 2016 (Group 1, 490 patients who underwent IPP placement between April 14, 2012 and April 13, 2014 and received a lower dose of preoperative gentamicin at 80mg/person; Group 2, 407 patients who underwent IPP placement between April 14, 2014 to April 13, 2016 and received a higher dose of preoperative gentamicin at 5mg/kg) and compared the infection rates of IPP. All the procedures were performed by one expert surgeon. Potential toxicities from the higher dose of gentamicin were closely monitored. There were no significant differences in mean age, mean body mass index (BMI), and mean interval between the IPP placement and IPP infection, between the 2 groups. No toxicity was seen with the higher gentamicin dose. There were 6 cases in Group 1 (5 de-novo cases and 1 redo case, infection rate 1.22%) and 3 cases in Group 2 (2 de-novo cases and 1 redo case, infection rate 0.74%) who were found to have IPP infection. The infection rate in Group 2 appeared to be lower compared to that of Group 1, even though a significant statistical difference was not achieved (p=0.057).