043 Relationship Between Endogenous Testosterone and Lipid Parameters: Insight from REDUCE Study Group Database

Abstract

Puberty and exogenous androgens have been known to induce an increase in total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triclycerides, but decrease high-density lipoprotein cholesterol (HDL-C). This has led to the hypothesis that testosterone has a negative effect on lipid parameters and cardiovascular health. This study aimed to evaluate the relationship between lipid parameters and endogenous testosterone levels in a cohort of men from the REDUCE Study Group database. The REDUCE Study Group database was queried and 800 men with baseline testosterone and lipid data (total cholesterol, HDL-C, LDL-C, and triglycerides). The relationship between baseline testosterone levels and lipid parameters were analyzed using univariate and multivariate analyses. Higher total cholesterol and triglycerides are associated with lower total testosterone while higher HDL-C and LDL-C are associated with higher total testosterone. On multivariate analysis, for each increase in 1 mmol/L (about 39 ng/dL) of total cholesterol there is a decrease of 0.18 nmol/L in total testosterone (about 5 ng/dL). For each increase of 1 mmol/L (about 39 ng/dL) in HDL there is an increase of 1.10 in total testosterone (about 32 ng/dL).