039 Functional profile of circulating eosinophils in atopic dermatitis

Abstract

Atopic dermatitis (AD) may be accompanied by an increase in blood eosinophil (Eos) levels. A role for Eos in the pathophysiology of this disease is therefore suspected but not yet elucidated and justifies the need to clarify their functional profile. We conducted a prospective monocentric study that assessed the Eos phenotype between patients with moderate to severe AD (aged over 18 who fulfilled with AD UK working party criteria and presented a moderate or severe form of AD defined by SCORAD score ≥ 25 and/or EASI score ≥ 7) and healthy subjects (aged over 18, without atopic comorbidities or immunomodulatory treatment).