0381 Association of Social Jetlag with the 2018 WCRF/AICR Cancer Prevention Score Among Parent-Adolescent Dyads in the FLASHE Study

Abstract

Abstract Introduction Social jetlag (SJL), or the mismatch between biological and social time, is a marker of circadian misalignment. SJL is linked to biological and behavioral alterations (e.g., adiposity, unhealthy food intake) which over time may increase cancer and chronic disease risk. While developmental changes exacerbate SJL among adolescents, parents may also influence adolescent behavioral patterns. This study examined associations of SJL with multiple cancer preventive behaviors among parent-adolescent dyads using the 2018 World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) Cancer Prevention Score in the National Cancer Institute’s Family Life, Activity, Sun, Health, and Eating (FLASHE) Study. Methods Online cross-sectional surveys examining cancer-preventive behaviors were administered to 1,479 parent-adolescent (aged 12-17y) dyads in 2014. SJL was defined as the absolute difference between sleep midpoint on weekend and week days. The adapted 2018 WCRF/AICR Score ranged from 0-6 and was the sum of six sub-components representing adherence to specific cancer prevention recommendations concerning body weight, physical activity, and diet. Dyads with missing data on either variable were excluded. Actor-partner interdependence modeling was used to determine within-dyad correlations, actor (i.e., effect of a dyad member’s SJL on own score), and partner (i.e., effect of a dyad member’s SJL on partner’s score) effects. Results The analytical sample included 936 dyads. Mean SJL was 2.0 hours (SD: 1.2) for adolescents and 1.2 hours (SD: 0.9) for parents. Mean WCRF/AICR Scores were 4.1 (SD: 0.9) for adolescents and 4.0 (SD: 0.9) for parents. Within dyads, SJL (r=0.29) and the WCRF/AICR Score (r=0.41) were positively correlated (all p <0.0001). Among adolescents, greater SJL was associated with a lower WCRF/AICR Score (β= -0.077, SE: 0.03, p=0.003), but this relationship was not observed among parents. No partner effects were detected. Conclusion Among adolescents, SJL was associated with poorer adherence to cancer prevention recommendations. SJL may represent a modifiable risk factor with the potential to improve multiple health behaviors and decrease disease risk. Support FLASHE was funded with federal funds from the National Cancer Institute, National Institutes of Health (NIH), under contract number HHSN261201200039I issued to Westat, Inc