Abstract
Interleukin-1 alpha (IL-1α) is constitutively expressed in epithelial cells located at barrier sites, such as skin, lung, and gut. Upon cellular death, injury or infection, IL-1α is released. Serum levels of IL-1α are largely undetectable in healthy volunteers (HV), or atopic dermatitis (AD) and hidradenitis suppurativa (HS) patients, while levels in the skin, especially in the epidermis and exudates from HS tunnels, are highly concentrated. Bermekimab (BMK) is a first-in-class fully human anti-IL-1α monoclonal antibody that has been tested in Phase-2A AD and HS studies.
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