Abstract
Diphencyprone (DPCP) is a hapten that induces delayed-type hypersensitivity (DTH) reactions and is used therapeutically for various conditions including alopecia areata and melanoma metastases. Prior work has shown gene expression markers of major T cell subsets (Th1, Th2, and Th17) are significantly increased at 3 days after a single application of DPCP in healthy volunteers. We evaluated the cutaneous proteome of DPCP reactions in the skin of eight healthy volunteers at days 3, 14, and 120 after application.
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