Abstract
Pathogenic memory T cells are implicated in the local relapse of allergic contact dermatitis (ACD), vitiligo and psoriasis. Here we investigate how resident T cells initiate relapses in response to the allergen Methylisothiazolinone (MI). MI–related ACD was sampled two months and two years after resolution of disease. T cells were activated in skin explants with MI or the pan T-cell agonist OKT-3. Epidermis was analysed by RNAseq, Nanostring and multiplex methods. Metalloproteinase 12 (MMP-12)–induction by ACD–related cytokines was assessed in primary keratinocytes and fibroblasts and a humanized xenograft mouse model was used.
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