0345 : Prevalence and risk factors of valvular calcification in hemodialysis patients

Abstract

Valvular abnormalities frequently occur in patients with chronic kidney failure. This study evaluated the prevalence of heart valve calcification (HVC) in hemodialysis patients and factors associated with it. Medical charts of 111 hemodialysis patients were reviewed retrospectively. Demographic features and laboratory analysis of the patients were systematically recorded. Echocardiographic findings were collected, including ejection fraction, aortic valve calcification (AVC), mitral valve calcification (MVC), and pulmonary artery pressure. Valvular abnormalities were found in 17 patients (15,3%); 7 patients (6.3%) had mitral valve calcification, 7 (6.3%) had aortic valve calcification, and 3 (2.7%) had both mitral and aortic valve calcification. There is a significant difference between patients with and without HVC regarding serum albumin (41g /l vs 43g/l; p=0.04), CRP rate (23mg/l vs 9,3mg/l; p=0.0094), and taking calcium carbonate (15 patients vs 2; p=0.04). Regarding age, sex, the lipid profile, serum calcium, and parathyroid hormone concentrations, there were no significant differences between patients with and without HVC. This study failed to show an association between heart valve calcification in hemodialysis patients and calcium-phosphorus product and parathyroid hormone levels; however, serum albumin level and CRP rate could be regarded as risk factors.