Abstract
To prevent acute life-threatening auto-inflammation/autoimmune of the tissues, our immune system must mount protective immunity, and rapidly resolve inflammation. Dendritic cells (DCs) are specialized immune sentinels that maintain immune homeostasis by efficiently regulating the balance between protective immunity and tolerance to self-antigens. It is critical to understand how tissue DCs subsets and their tissue specificity are governed to mediate protective or tolerant immunity. By assaying chromatin accessibility of LN resident (cDC1 vs cDC2) and migratory DCs (migDC1 vs migDC2) genome-wide through ATACseq analysis, together with our prior lab work using RNAseq analysis, we found that tissue myeloid maturation and migration programing supersedes subset diversification, and is enforced at the level of the chromatin.
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