033 Bullous pemphigoid autoantibodies induce keratinocyte PAI-1 expression resulting in decreased plasmin activation

Abstract

Bullous pemphigoid (BP) has been associated with an increase in venous thromboembolism due to impaired fibrinolysis. As plasma levels of plasminogen activator inhibitor type 1 (PAI-1) are elevated in BP patients, this represents one possible mechanism. We sought to better understand the role of BP autoantibodies in inducing a prothrombotic state. We first reviewed our previous RNA-seq database of BP-IgG treated keratinocytes relative to controls, confirming overexpression of SERPINE1 (Log2fold (1.01 P-adjusted < 0.0001).