0306 Normative Data of Cyclic Alternating Pattern across the Lifespan

Abstract

Abstract Introduction Cyclic alternating pattern (CAP) is a marker of sleep instability, and neuroplasticity. Slow wave sleep has been described as a stable period, and CAP can be a marker of funcional delta sleep. The aim of this review was to evaluate the normative data of CAP parameters according to the aging process in healthy subjects. Methods Two authors independently searched databases using PRISMA guidelines through a systematic review and meta-analysis. Subgroup analysis and tests for heterogeneity were conducted. Descriptive statistics were used for the analysis of CAP variables. Meta-analyses were performed by using Comprehensive Meta- Analysis software. Data extracted from tables provide Results We found the evolution of CAP rate across the lifespan. Squares and diamond represent the CAP mean while bars represent the CAP range between 95% CI values according to each age range. We analysed 168 healthy individuals by CAP analyses. Scoring of CAP can begin at 3 months of life, when K-complexes, delta bursts, or spindles can be recognized. Rate of CAP increased with age, mainly during the first 2 years of life, then decreased in adolescence, and increased in the elderly. The A1 CAP subtype and CAP rate were high in school-aged children during slow-wave sleep (SWS). Our meta-analysis registered the lowest CAP rate in infants younger than 2 years old and the highest in the elderly. Conclusion The normative data of CAP in NREM sleep can be connected with brain maturation.The CAP rate increased with age and sleep depth, especially during SWS. These data in sleep disorders can be a treatment goal. CAP may reflect neurodiversity of endophenotype and human cronobiotypes. Further studies about CAP subtypes are needed. Support (If Any)