Abstract
Diabetes is associated with a significantly increased risk of microvascular disorders, including retinopathy, nephropathy, and neuropathy, as well as macrovascular complications, such as atherosclerosis and cardiovascular disease. Traditionally, micro- and macrovascular complications have been considered separate and distinct disorders; however, accumulating evidence suggests the two may be linked. We hypothesize that diabetes-associated accelerated atherosclerosis results from the direct effects of hyperglycemia on the vasa vasorum, the microvascular network which supplies the cells within the walls of large muscular arteries.
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