Abstract
To evaluate the effectiveness of balloon-occluded TACE (b-TACE) vs conventional-TACE by measuring doxorubicin concentration in the VX2 tumors and normal liver parenchyma. This study was conducted with OHSU’s institutional animal care and use committee for approval. A total of 17 rabbits subsequently underwent surgical implantation of two VX2 tumors in their medial and lateral lobes. The b-TACE (8 rabbits) or c-TACE (9 rabbits) was performed approximately 3 weeks after the implantation. Emulsion of 5 mg/ml doxorubicin and Lipiodol in 1:1 ratio was delivered at proper hepatic arteries through 1.8-French-tip balloon microcatheters for b-TACE group or 1.9-French-tip non-balloon microcatheters for c-TACE group. The tumors were harvested immediately after the procedure and the tumors were processed for tissue liquid chromatography-tandem mass spectrometry (LC-MS/MS) doxorubicin analysis. A total of 34 tumors (16 tumors and 18 tumors, b-TACE vs. c-TACE) were harvested and analyzed with LC-MS/MS. The maximum diameters of the tumors were 22.6±6.94 mm vs. 21.7±6.97 mm. The amount of doxorubicin given was 3.60±0.97 mg vs. 3.61±1.17 mg. The doxorubicin concentrations of both peripheral and central portions of the tumors were 1.95±1.67 vs.1.22±1.67 mcg/ml (b-TACE vs. c-TACE, p=0.203) and 1.14±1.22 vs. 0.76±1.22 mcg/ml (b-TACE vs. c-TACE, p=0.334). The doxorubicin concentrations of normal liver tissue were 1.18±1.32 vs. 0.72±0.70 mcg/ml (b-TACE vs. c-TACE, p=0.07). Combined the both groups, concentration of doxorubicin in peripheral portion of the tumors were statistically significantly higher than that of in central portion (1.65±1.37 vs. 0.90±0.89 mcg/ml, p=0.044). The b-TACE may introduce higher dose of doxorubicin into the tumors and normal liver parenchyma as well compared with c-TACE. The doxorubicin concentration was significantly higher in the peripheral portion of the tumors than that of central.
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