Abstract
Manganese (Mn) is a known neurotoxicant, and given its health effects and ubiquitous nature in metal-working settings, identification of a valid and reproducible biomarker of exposure is of interest. Global...
Highlights
Global metabolomics were previously utilised to determine metabolites that differ between occupational groups defined by Mn exposure status, in hopes of informing a biomarker of exposure
Job-exposure matrixes (JEM) approaches have been recently developed on physical workload in US, Denmark and France
The Danish JEMs were based on occupational titles in the Danish version of the International Standard Classification of Occupations 1988 (ISCO88)
Summary
INVESTIGATING THE REPRODUCIBILITY OF METABOLOMICS PROFILES OF WASHINGTON STATE METAL WORKERS. Nine metabolites were found to differ between exposure groups in urine samples collected October 2014. To test the reproducibility of these metabolites, these nine metabolites were investigated in a second set of urine samples collected January 2015 from the same workers. Metabolomics is a novel technique for exposure assessment, but few studies have looked at the reproducibility of metabolomics data by collecting repeat samples from the same workers. This analysis found several ions that do seem to remain stable over time, and identification of these ions should be pursued as potential biomarkers of Mn exposure
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