Abstract
Fixed drug eruption (FDE) repeats in the same sites and the lesions increase by repetitive exposure to the causative drug. Although FDE is regarded to be mediated by skin resident memory T cells (TRM), which are sessile and do not recirculate from skin, the clinical characteristics of FDE cannot be fully explained by the known functions of TRM in human. In order to elucidate the contribution of TRM in the FDE manifestation, skin T cells isolated from lesions of total five recurrent and four cured FDE subjects, and total seven controls from surgical discards were analyzed for the expression of cell-surface molecules representing the phenotypes of TRM and central memory T cells (TCM) by flow cytometry.
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