Abstract

Pemphigus Vulgaris (PV) has one of the strongest known HLA disease associations. The majority of PV patients studied carry either DRB1*0402 or DQB1*0503. However, studies on HLA associations in PV have largely focused on populations with specific ethnic backgrounds, often Ashkenazi Jewish (AJ) and non-Jewish Caucasians and there are limited studies on patients of African descent. We investigated the HLA status of 11 African American (AA) PV patients in comparison to 282 patients of non-African descent to identify HLA-associations and potential disease relevance in this understudied population.

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