0260: Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients, a deformation imaging study

Abstract

We aimed to investigate left atrium (LA) function by speckle tracking echocardiography in women with metabolic syndrome (MetSyn) admitted in chest pain unity with normal coronary angiography and to show a possible relationship between the severity of MetSyn and LA function we included 180 MetSyn patients without diabetes and 50 controls. The patients were classified into three groups based on the number of MetSyn criteria. The peak LA strain at the end of the ventricular systole (LAs-strain) as well as the LA strain with LA contraction (LAa-strain) was obtained. Correlation analysis performed to assess the association of LA strain parameters with the severity of MetSyn and logistic regression analysis performed to assess the relationship of low LA strain with MetSynd Both LAs (33.5±6.7 vs. 24.3±11.2, p<0.01) and LAa (20.4±4.2 vs. 13.0±6.4, p<0.001) strain measurements were found to be significantly decreased in patients with MetSyn when compared to the control group. Moreover, both LAs and LAa were found to be significantly decreased with the increasing severity of the MetSyn. A multiple logistic regression analysis demonstrated that the presence of MetSyn [OR:0.34 (95% CI 0.04-0.89), p=0.032] and left ventricular ejection fraction [OR:1.23 (95% CI 1.02-1.77), p=0.03] were independent predictors of LAs strain. MetSyn is associated with reduced LAs strain and LAa strain representing LA reservoir and pump function, respectively. Furthermore, LA mechanical function decreases even more with the increasing severity of the MetSyn.