0221 Pre-Sleep Breath alcohol concentrations (psBrAC) and sleep polysomnography (PSG)

Abstract

Abstract Introduction Alcohol use before bedtime has been shown to alter sleep including decreasing sleep latency, decreasing sleep efficiency, and fragmenting sleep stage distribution. Few studies manipulate pre-sleep alcohol concentration, instead focusing on a target dose or peak alcohol concentration during the night. Thus, we investigated how presleep breath alcohol concentrations (psBrAC) level (targeting a BrAC of 0.08), are associated with same-night sleep. Methods Thirty (15F; ages=22-57, mean=33yr) healthy adults who self-reported moderate drinking were instructed to maintain a consistent sleep schedule (8-9h time in bed) for a least 7-days before entering a cross-over design involving two sets (separated by>3 days) of 3 consecutive nights of in-lab polysomnography. For all nights in each condition, participants drank either mixer alone or mixer+alcohol in 3 portions across 45 minutes ending 1h before lights out. psBrAC was measured within 5 minutes of lights out. PSGs were staged according to Rechtschaffen and Kales (1968). We computed: slow wave sleep (SWS) and REM as percentages of total sleep for the full night (%SWS) & (%REM), %SWS in the first third of the night (%SWST1), %REM in the last third of the night (%REMT3), minutes until sleep onset from lights out (Sleep Latency), and minutes after sleep onset until REM onset. Linear regressions tested if psBrAC on the first mixer+alcohol night predicted changes in sleep using the average of the three nights of sleep in the mixer-only condition as a covariate. Results psBrAC values ranged from 0.038 to 0.087 (mean = 0.066) mg/L. We identified minimal influence of BrAC on sleep: % SWS (β = -0.78; p = 0.07), % REM (β = 0.032; p = 0.96), % SWS T1 (β = -0.52; p = 0.522), % REM T3 (β = -1.01; p = 0.125), REM latency (β = 3.95; p = 0.302), and sleep latency (β = -1.23; p = 0.13). Conclusion These findings indicate that psBrAC was not associated with any of our sleep variables, when adjusting for sleep on nights without alcohol. Future work will examine peak BrAC as well whether the effects observed change over multiple nights of pre-sleep alcohol consumption. Support (If Any) R01AA025593