Abstract
Infertility remains one of the most common and life-altering complications experienced by women treated for cancer during childhood, adolescence, and young adulthood. The risk of infertility is generally related to the tissues/organs involved by cancer and the specific type, dose, and combination of gonadotoxic therapy. In addition to anti-cancer therapy, age at treatment, and likely genetic factors influence the risk of permanent infertility. Long-term adverse health outcomes of cancer treatment on the female reproductive system include ovarian hormone insufficiency and reduced ovarian follicular pool, which can clinically manifest premature ovarian insufficiency (delayed or arrested puberty, early menopause) and infertility.
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