0216 COMPARISON OF THE ASSOCIATION OF EXECUTIVE FUNCTION WITH SELF-REPORTED AND OBJECTIVE SLEEP IN HEART FAILURE PATIENTS

Abstract

Executive dysfunction is common in heart failure patients1 and associated with poor functional status.2 Sleep problems, reported by approximate 67% of heart failure patients,3 may contribute to executive dysfunction.4,5 Studies have been limited by use of only self-reported sleep measures and objective sleep data are lacking. The aims are to (1) investigate the association between executive function with objective sleep and (2) compare the association between executive function and self-reported and objective sleep in heart failure patients. This study analyzed baseline data from a longitudinal intervention study. Data were collected from 170 heart failure patients (age: 60.5 10.9, female: 44.7%, NYHA ǀ/ǁ/III/IV: 9.5%/52.1%/37.3%/1.2%). Executive function was measured by letter fluency test. Higher score indicates better executive function. Self-reported sleep was determined by the converted total score of PROMIS-Sleep Disturbance instruments v.1.0. Higher score indicates more sleep disturbances. Objective sleep by at least 3 nights of waist actigraphy. Descriptive statistics, Pearson’s correlation, and hierarchical multiple regression were used to analyze data (covariates: age, gender, education, body mass index, comorbidity, medications, depression, anxiety, fatigue, and ejection fraction). Better executive function was significantly correlated with more self-reported sleep disturbances (r= 0.19, p=.015). No actigraph sleep variables significantly correlated with executive function. After controlling covariates, the model of self-reported sleep disturbances significantly predicted executive function [n=163, R2 changes= .016, F(12, 150)= 1.92, p=.036]; however, the variable of sleep disturbances was not a significant predictor (=0.16, p=.103). After controlling covariates, the model of objective sleep was not predictive [n=163, R2 changes= .002, F(15, 147)= 1.33, p=.190]. Neither self-reported sleep disturbances nor objective sleep were associated with executive dysfunction in this sample. Results need to be confirmed by further evaluation of sleep and use of additional tests of executive function beyond the letter fluency. NIH Funding number: R01 HL112979.